After providing all the funding for The Brain from Top to Bottom for over 10 years, the CIHR Institute of Neurosciences, Mental Health and Addiction informed us that because of budget cuts, they were going to be forced to stop sponsoring us as of March 31st, 2013.

We have approached a number of organizations, all of which have recognized the value of our work. But we have not managed to find the funding we need. We must therefore ask our readers for donations so that we can continue updating and adding new content to The Brain from Top to Bottom web site and blog.

Please, rest assured that we are doing our utmost to continue our mission of providing the general public with the best possible information about the brain and neuroscience in the original spirit of the Internet: the desire to share information free of charge and with no adverstising.

Whether your support is moral, financial, or both, thank you from the bottom of our hearts!

Bruno Dubuc, Patrick Robert, Denis Paquet, and Al Daigen




Tuesday, 8 October 2024
The “forest troop” : a tale of baboons about our world ?

Primatologist Robert Sapolsky studied a troop of baboons in Kenya for many years. Around the mid-1980s, the dominant males in this troop began raiding a garbage dump near a tourist lodge, where they ate meat that was infected with tuberculosis and ended up killing them. Because the most aggressive males in the troop had thus been killed off, the troop as a whole became more peaceful. There was still a hierarchy, but it had become much less rigid. This new pattern persisted even 10 to 20 years later, when all of the males then in the troop had been born in different ones (male baboons leave their natal troops and join others once they reach reproductive age). These males born in other troops had no need to be so aggressive in this especially peaceful baboon culture (until then, ethologists had always described baboons as especially aggressive animals). I wonder what might happen if all of the most aggressive, dominant men running the world’s empires today were suddenly to die from, say, eating contaminated caviar. You may laugh, but this natural experiment with baboons raises many questions about the supposedly unavoidable aspects of human societies.

Emotions and the Brain, Mental Disorders | Comments Closed


Tuesday, 17 September 2024
Spectacular reconstructions of the neurons of the human cortex

The problem with scientific research is that it never stops. Recently, my friend Jean-Pierre, who keeps a close eye on new articles in major neuroscientific journals, let me know about a major paper just published in Science, about how electron microscopy is now being used to reconstruct neurons of the human cortex with unequalled precision. And since this research had been done by Jeff Lichtman’s team at Harvard, and I had already written a post about it in this blog back in 2014 , I figured that I had better write another post about it now, because the images of neurons that this team has succeeded in producing recently are truly spectacular. For example, the image above represents one neuron with 5600 axons (blue) making synaptic connections (green)). (more…)

From the Simple to the Complex | Comments Closed


Monday, 19 August 2024
Discovery of the “jailer” in our neurons

Today I’d like to say a few words about a phenomenon that is related to neuronal plasticity and that I’d never heard of before. I learned about it in a book entitled Seeing the Mind: Spectacular Images from Neuroscience, and What They Reveal about Our Neuronal Selves, by French cognitive psychologist Stanislas Dehaene. Actually, I read the original French edition, published in 2021, but I don’t have access to the English edition, published in 2023, so the following excerpt is my own translation:

As we age, certain neurons, and especially the large inhibitory neurons that control the activity of their surroundings, become wrapped in a perineuronal net,a rigid lattice that holds them still. This aggregate of proteins and sugar chains, which has some of the same ingredients as cartilage, prevents the nerve cells from changing. Hence they cannot form new connections or even alter existing ones; emprisoned in this net, the neuron loses its plasticity.

(more…)

From the Simple to the Complex | Comments Closed


Wednesday, 24 July 2024
How Andy Clark’s career path mirrors that of cognitive science over the past 40 years

This week I’m just going to copy and paste a paragraph from a chapter of my book ( to be released in French on October 1, 2024 ) in which I describe the career of Andy Clark, an important philosopher of cognitive science, and draw your particular attention to his latest book, The Experience Machine: How Our Minds Predict and Shape Reality, which he discusses in this stimulating interview.

I will start by just briefly describing the career of Andy Clark, a philosopher of cognitive science whom I like a lot, and his encounter with Karl Friston. Because Clark’s career path, all on its own, sums up the major trends in cognitive science over the past 40 years that I talked to you about at our first meeting. First, in keep with the cognitivist paradigm that prevailed at the time, he studied symbolic artificial intelligence, also known as computationalism. Then he became interested in connectionism— in virtual neural networks, thus more closely approximating the human brain, which can learn by modifying its internal connections. After that, he jumped aboard the train of embodied cognition, thus including the entire body in the equation of our cognitive processes, and even the objects in our environment (the concept of extended cognition, of which is he one of the most ardent proponents). And lastly, he made important contributions to the Karl Friston’s bold ideas about predictive processing, the principle of free energy and active inference—in short,all of the concepts whose broad implications I will now discuss.

 

From the Simple to the Complex, From Thought to Language | Comments Closed


Tuesday, 25 June 2024
Earworms as an excuse to talk about mental simulations and working memory

This week I’d like to talk about an intriguing phenomenon: earworms, those bits of songs that start playing in your head for hours and sometimes even days on end. More specifically, I’d like to talk about a comment that biologist John Medina makes about earworms in an entry entitled “As the Worm Turns” in his substack “John Medina’s Brain Rules”. I call it a comment because, as Medina admits right off, no one really knows much about what causes earworms. But the two neurological considerations that he raises are still interesting. They relate to two key concepts that I of course discuss on my website: mental simulation and working memory. (more…)

Memory and the Brain | Comments Closed