After providing all the funding for The Brain from Top to Bottom for over 10 years, the CIHR Institute of Neurosciences, Mental Health and Addiction informed us that because of budget cuts, they were going to be forced to stop sponsoring us as of March 31st, 2013.

We have approached a number of organizations, all of which have recognized the value of our work. But we have not managed to find the funding we need. We must therefore ask our readers for donations so that we can continue updating and adding new content to The Brain from Top to Bottom web site and blog.

Please, rest assured that we are doing our utmost to continue our mission of providing the general public with the best possible information about the brain and neuroscience in the original spirit of the Internet: the desire to share information free of charge and with no adverstising.

Whether your support is moral, financial, or both, thank you from the bottom of our hearts!

Bruno Dubuc, Patrick Robert, Denis Paquet, and Al Daigen




Friday, 28 February 2020
The multiple levels of organization of living things: more central than ever to cognitive science

This week I want to talk about a concept that is fundamental to an understanding not only of the human brain but also of the entire human adventure in general: the various levels of organization of living systems. This concept is central to the most influential current studies in theoretical biology, if one is to judge from the article “Answering Schrödinger’s question: A free-energy formulation”, by Maxwell Ramstead of McGill University’s Department of Psychiatry and his colleagues Paul Badcock and Karl Friston, published in March 2018 in the journal Physics of Life Reviews. While I will not delve here into the details of the free-energy principle that is central to all these studies, I will describe this article as the first attempt to explain the dynamics of cognitive systems at every scale on which they occur. In other words, these three authors attempt to consider every behaviour of living beings as the product of “nested systems of systems”. (more…)

From the Simple to the Complex, Memory and the Brain | Comments Closed


Wednesday, 5 February 2020
Blood-glucose levels influence judges’ decisions less than we think

Science is based on empirical facts, such as data gathered in experiments. But it is also based on the interpretation of these facts, what they mean, what may have made them possible. (In scientific articles, the data—the facts—are presented in the “Results” section and interpreted in the “Discussion” section.) It should be no surprise that in any given field of science, some scientists may disagree with the way that their colleagues have interpreted certain results. Such disagreements arise in all scientific disciplines, especially in psychology, and especially when the data are very clear-cut or the correlations are very strong. And it’s just that kind of a case that I’d like to discuss in this post today (maybe in some future post, I will discuss the broader results-reproducibility crisis that has been shaking psychology for some years now). (more…)

From Thought to Language | Comments Closed


Wednesday, 8 January 2020
The Glymphatic System: The Sewers of the Brain

As has been well established, the human brain consumes tremendous amounts of energy: about 20 to 25% of all the energy that the body uses, even though this organ accounts for only 2% of the body’’s total weight. As a result, the brain necessarily produces large amounts of waste—the equivalent of its own weight in waste every year! But this waste can be toxic to the brain itself. How the brain gets rid of this waste was long a mystery to scientists. Some thought that the brain might cleanse itself through passive diffusion of cerebrospinal fluid from the cerebral ventricles, but this seemed like a very slow waste-removal mechanism for such an active organ as the brain. It was not until 2012 that studies on mice showed that the brain has its own specific waste-removal mechanism that is faster and more efficient.. (more…)

From the Simple to the Complex | Comments Closed


Monday, 25 November 2019
Three On-Line Atlases of the Human Brain

This week I want to tell you about three different on-line atlases of the human brain. All three will let you satisfy your curiosity by exploring the inmost recesses of the most complex object in the known universe, of which each of us has an example right between our ears. So stand warned: this post may well leave you spending even more time on your computer than usual! (more…)

From the Simple to the Complex, Uncategorized | Comments Closed


Tuesday, 22 October 2019
Why forgetting can save your life

When we think about human memory, it tends to be with the implicit assumption that more is always better. But more and more neurobiologists are now asserting the opposite: that forgetting makes us more efficient! This raises two important questions: 1) forgetting what? and 2) more efficient in doing what? Science blogger Tom Siegfried attempts to provide the answers in an article published in January 2019, entitled “Why forgetting may make your mind more efficient.” (more…)

Memory and the Brain | Comments Closed