After providing all the funding for The Brain from Top to Bottom for over 10 years, the CIHR Institute of Neurosciences, Mental Health and Addiction informed us that because of budget cuts, they were going to be forced to stop sponsoring us as of March 31st, 2013.

We have approached a number of organizations, all of which have recognized the value of our work. But we have not managed to find the funding we need. We must therefore ask our readers for donations so that we can continue updating and adding new content to The Brain from Top to Bottom web site and blog.

Please, rest assured that we are doing our utmost to continue our mission of providing the general public with the best possible information about the brain and neuroscience in the original spirit of the Internet: the desire to share information free of charge and with no adverstising.

Whether your support is moral, financial, or both, thank you from the bottom of our hearts!

Bruno Dubuc, Patrick Robert, Denis Paquet, and Al Daigen





Tuesday, 19 September 2023
Mechanisms underlying anatomical the tracing methods

Today I’d like to tell you about the cellular mechanisms underlying the tracing methods used to visualize the paths that axons follow from one structure in the brain to another. The use of these methods in animal models is based on the ability that neurons have to move molecules along the microtubules in their axons. This process is essential to the normal functioning of neurons and is known as axonal transport. It works by means of motor proteins that, when supplied with a bit of energy, constantly change form to drive all kinds of molecules carried in vesicles, a bit like a porter with a load on his back. There are some animations on the Internet that illustrate this process, and it’s pretty impressive! (more…)

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